NSAID induced nephropathy
Will use of NSAID (Motrin, Ibuprofen and Advil) cause kidney disease?
Long-term NSAID use can lead to chronic kidney disease (CKD). Non-steroidal anti-inflammatory drugs (NSAIDs) such as Motrin, ibuprofen, Advil naproxen sodium etc.. are commonly used medications for pain and fever which can lead to kidney disease, especially when used for a long time.
How are the kidneys affected?
- NSAID can cause inflammation in the kidney tubules by reducing blood flow to the kidneys
Who can get kidney disease from NSAID?
- People who are advanced in age and who have comorbidities (diabetes and hypertension)
- Those taking higher than prescribed dose
- Those taking NSAID for more than prescribed time period
- Those taking NSAIDS without consulting their physician
Side effects of NSAID
- Ulcers in the stomach, stomach pain, and nausea
- Liver cirrhosis
- Clot formation
How much NSAID is safe to take in 24 hours:
- This is based on your unique health condition
- However, normal adults and teenagers can take up to 1200 mg per every 24 hours, not more than prescribed amount of time
- For children, the use of NSAID is weight based – please consult pediatrician about dose and duration
- Lucas, G., Leitão, A., Alencar, R. L. Xavier, R., Daher, E. F., & Silva Júnior, G. (2019). Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs. Jornal brasileiro de nefrologia : ‘órgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia, 41(1), 124–130.